GFRα-4, a new GDNF family receptor

被引：75

作者：

Thompson, J ^{[1
]}

Doxakis, E ^{[1
]}

Piñón, LGP ^{[1
]}

Strachan, P ^{[1
]}

Buj-Bello, A ^{[1
]}

Wyatt, S ^{[1
]}

Buchman, VL ^{[1
]}

Davies, AM ^{[1
]}

机构：

[1] Univ St Andrews, Sch Biomed Sci, St Andrews KY16 9TS, Fife, Scotland

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 1998年 / 11卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/mcne.1998.0682

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GFR alpha-1, GFR alpha-2, and GFR alpha-3 constitute a family of structurally related, glycosyl-phosphatidylinosital-linked, cell surface proteins, two of which, GFR alpha-1 and GFR alpha-2, are components of the receptor complex for the neurotrophic factors GDNF and neurturin, respectively. By screening an embryonic chicken brain cDNA library with a GFR alpha-1 probe at low stringency, we isolated cDNAs encoding an additional member of the GFR alpha family, GFR alpha-4. The nucleotide sequence predicts a 431-amino-acid secreted protein that is more closely related to GFR alpha-1 and GFR alpha-2 than to GFR alpha-3. GFR alpha-4 mRNA is expressed in distinctive patterns in the brain and several other organs and tissues of the chicken embryo. Our findings extend the family of GFR alpha proteins and provide information about the tissues in which GFR alpha-4 may function during development.

引用

页码：117 / 126

页数：10

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