Atherosclerotic lesions in mouse and man: is it the same disease?

被引：115

作者：

Bentzon, Jacob Fog ^{[1
]}

Falk, Erling

机构：

[1] Aarhus Univ Hosp, Atherosclerosis Res Unit, Inst Clin Med, DK-8200 Aarhus N, Denmark

来源：

CURRENT OPINION IN LIPIDOLOGY | 2010年 / 21卷 / 05期

关键词：

animal model; atherosclerosis; hypercholesterolemia; transgenesis; APOE-DEFICIENT MICE; HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA; CORONARY-ARTERY-DISEASE; DOUBLE KNOCKOUT MICE; SMOOTH-MUSCLE-CELLS; E-NULL MICE; APOLIPOPROTEIN-E; PLAQUE RUPTURE; 5-LIPOXYGENASE; GENE;

D O I：

10.1097/MOL.0b013e32833ded6a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Murine atherosclerosis models are highly valuable for identifying atherogenic mechanisms that can be targeted by preventive medicine. However, models with thrombotic complications and large animal models suitable for interventional procedures and imaging would be more supportive for current clinical practice and are highly wanted.

引用

页码：434 / 440

页数：7

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