Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex

被引：95

作者：

Kennedy, MK

Park, LS

机构：

[1] Immunex Corporation, Seattle, WA 98101-2936

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1996年 / 16卷 / 03期

关键词：

interleukin-15 (IL-15); IL-15; receptor; IL-2;

D O I：

10.1007/BF01540911

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-15 interacts with a heterotrimeric receptor that consists of the beta and gamma subunits of the IL-2 receptor (IL-2R) as well as a specific. high-affinity IL-15-binding subunit, which is designated IL-15R alpha. Since both the beta and the gamma subunits of the IL-2R are required for signaling by either IL-2 or IL-15, it is not surprising that these cytokines share many activities in vitro. However, the differential expression of these cytokines and the alpha chains of their receptors within various tissues and cell types suggests that IL-2 and IL-15 may perform at least partially distinct physiological functions. The production of IL-15 by macrophages, and possibly other cell types, in response to environmental stimuli and infectious agents suggests that IL-15 may play a role in protective immune responses, allograft rejection, and the pathogenesis of autoimmune diseases.

引用

收藏

页码：134 / 143

页数：10

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