Serum Helicobacter pylori CagA antibody as a biomarker for gastric cancer in east-Asian countries

被引：70

作者：

Shiota, Seiji ^{[1
]}

Matsunari, Osamu ^{[1
]}

Watada, Masahide ^{[1
]}

Yamaoka, Yoshio ^{[1
,2
,3
]}

机构：

[1] Oita Univ, Fac Med, Dept Environm & Preventat Med, Yufu City, Oita, Japan

[2] Baylor Coll Med, Dept Med Gastroenterol, Houston, TX 77030 USA

[3] Michael E DeBakey VA Med Ctr, Houston, TX USA

来源：

FUTURE MICROBIOLOGY | 2010年 / 5卷 / 12期

基金：

美国国家卫生研究院;

关键词：

anti-CagA antibody; east Asia; gastric cancer; Helicobacter pylori; VIRULENCE FACTOR CAGA; INCREASED RISK; THROMBOCYTOPENIC PURPURA; BIOLOGICAL-ACTIVITY; IMMUNE-RESPONSE; CARCINOMA RISK; 3' REGION; INFECTION; GENE; SEROPOSITIVITY;

D O I：

10.2217/FMB.10.135

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Aims: In east-Asian countries, while almost all Helicobacter pylori strains possess the cytotokine-associated gene A (CagA) gene, serum CagA antibody is not detected in some infected subjects. We aimed to clarify the association between anti-CagA antibody and gastric cancer in east-Asian countries. Materials and methods: We performed a meta-analysis of case-control studies with age- and sex-matched controls, which provided raw data in east-Asian countries. Results: Ten studies with a total of 4325 patients were identified in the search. Some reports from Japan, Korea and China showed a positive association between the presence of anti-CagA antibody and gastric cancer; however, the results differed in their various backgrounds. The disparate findings appeared to result from the use of different methods or from variations in the antigens used to detect the anti-CagA antibody. CagA seropositivity was associated with an increased risk of developing gastric cancer. Conclusion: Anti-CagA antibody can be used as a biomarker for gastric cancer even in east-Asian countries.

引用

页码：1885 / 1893

页数：9

共 64 条

[1]

[Anonymous], 1994, IARC Monogr Eval Carcinog Risks Hum, V61, P1

[2]

Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori [J].

Argent, RH ;

Kidd, M ;

Owen, RJ ;

Thomas, RJ ;

Limb, MC ;

Atherton, JC .

GASTROENTEROLOGY, 2004, 127 (02) :514-523

[3]

Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretion [J].

Argent, Richard H. ;

Hale, James L. ;

El-Omar, Emad M. ;

Atherton, John C. .

JOURNAL OF MEDICAL MICROBIOLOGY, 2008, 57 (09) :1062-1067

[4]

ASAKA M, 1994, CANCER, V73, P2691, DOI 10.1002/1097-0142(19940601)73:11<2691::AID-CNCR2820731107>3.0.CO

[5]

2-2

[6]

Guidelines for the Management of Helicobacter pylori Infection in Japan: 2009 Revised Edition [J].

Asaka, Masahiro ;

Kato, Mototsugu ;

Takahashi, Shin-ichi ;

Fukuda, Yoshihiro ;

Sugiyama, Toshiro ;

Ota, Hiroyoshi ;

Uemura, Naomi ;

Murakami, Kazunari ;

Satoh, Kiichi ;

Sugano, Kentaro .

HELICOBACTER, 2010, 15 (01) :1-20

[7]

Correlation between variation of the 3′ region of the cagA gene in Helicobacter pylori and disease outcome in Japan [J].

Azuma, T ;

Yamakawa, A ;

Yamazaki, S ;

Fukuta, K ;

Ohtani, M ;

Ito, Y ;

Dojo, M ;

Yamazaki, Y ;

Kuriyama, M .

JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (11) :1621-1630

[8]

Basso D, 1999, J CLIN LAB ANAL, V13, P194, DOI 10.1002/(SICI)1098-2825(1999)13:4<194::AID-JCLA9>3.0.CO

[9]

2-E

[10]

BLASER MJ, 1995, CANCER RES, V55, P2111

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