No Associations Between Single Nucleotide Polymorphisms in Corticoid Receptor Genes and Heart Rate and Cortisol Responses to a Standardized Social Stress Test in Adolescents: The TRAILS Study

被引：25

作者：

Bouma, Esther M. C. ^{[1
,2
]}

Riese, Harriette ^{[1
,2
,3
]}

Nolte, Ilja M. ^{[3
]}

Oosterom, Elvira ^{[4
]}

Verhulst, Frank C. ^{[5
]}

Ormel, Johan ^{[1
,2
]}

Oldehinkel, Albertine J. ^{[1
,2
]}

机构：

[1] Univ Groningen, Dept Psychiat, Interdisciplinary Ctr Psychiat Epidemiol, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Groningen Grad Sch Med Sci, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

[3] Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Unit Genet Epidemiol & Bioinformat, NL-9700 RB Groningen, Netherlands

[4] Univ Groningen, Dept Genet, Univ Med Ctr Groningen, Genome Anal Facil, NL-9700 RB Groningen, Netherlands

[5] Erasmus MC, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands

来源：

BEHAVIOR GENETICS | 2011年 / 41卷 / 02期

关键词：

Glucocorticoid receptor gene; Mineralocorticoid receptor gene; Non-replication; Multiple testing; False discovery rate; PSYCHOLOGICAL STRESS; ORAL-CONTRACEPTIVES; SENSITIVITY; DEPRESSION; PHASE; DETERMINANTS; EXPRESSION; VARIANTS; GENDER; IMPACT;

D O I：

10.1007/s10519-010-9385-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Previously, sequence variation in the glucocorticoid (GR) and mineralocorticoid (MR) receptor genes (NR3C1 and NR3C2, respectively) have been found to be associated with physiological stress responses to social stress tests in small samples of adult men and oral contraceptives (OC) using women. Associations between single nucleotide polymorphisms (SNPs) in the GR (23EK-rs6190, 9beta-rs6198, BclI-rs4142324) and the MR gene (I180V-rs5522 and -2G/C (rs2070951) with cortisol and heart rate responses to a performance-related social stress task (public speaking and mental arithmetic) were examined in a large sample (n = 553) of adolescents (15-17 years). To make comparisons with previous findings, associations were tested in boys (n = 277), free-cycling (FC) girls (n = 183) and OC users (n = 93). None of the previously reported associations in adults could be replicated in this large adolescent sample. Explanations for non-replication are discussed.

引用

页码：253 / 261

页数：9

共 44 条

[1]

Altemus M, 1997, NEUROPSYCHOPHARMACOL, V17, P100

[2] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].