POTRA:: a conserved domain in the FtsQ family and a class of β-barrel outer membrane proteins

被引：184

作者：

Sánchez-Pulido, L ^{[1
]}

Devos, D

Genevrois, S

Vicente, M

Valencia, A

机构：

[1] CSIC, CNB, Prot Design Grp, E-28049 Madrid, Spain

[2] Univ Namir, FUNDP, URBM, B-5000 Namur, Belgium

[3] CSIC, CNB, Microbiol Biotechnol, E-28049 Madrid, Spain

[4] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 10期

关键词：

D O I：

10.1016/j.tibs.2003.08.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

POTRA (for polypeptide-transport-associated domain) is a novel domain identified in proteins of the ShIB, Toc75, D15 and FtsQ/DivIB families. In most cases, the POTRA domain is associated with a beta-barrel outer membrane domain and its function has been experimentally related to polypeptide transport in Toc75 (Tic-Toc protein import system in chloroplast) and ShIB families. In addition to potential key roles in protein transport across the outer membrane and in bacterial septation, the POTRA domain has attractive features for vaccine development in diseases such as cholera, meningitis, gonorrhoea and syphilis.

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收藏

页码：523 / 526

页数：4

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