Multiple system atrophy/progressive supranuclear palsy:: α-Synuclein, synphilin, tau, and APOE

被引：47

作者：

Morris, HR

Vaughan, JR

Datta, SR

Bandopadhyay, R

de Silva, HAR

Schrag, A

Cairns, NJ

Burn, D

Nath, U

Lantos, PL

Daniel, S

Lees, AJ

Quinn, NP

Wood, NW

机构：

[1] Inst Neurol, Neurogenet Sect, London WC1N 3BG, England

[2] Inst Neurol, Movement Disorders Sect, London WC1N 3BG, England

[3] Inst Neurol, Parkinsons Dis Soc, Brain Res Ctr, London WC1N 3BG, England

[4] Inst Neurol, Univ Dept Clin Neurol, London WC1N 3BG, England

[5] Inst Psychiat, Dept Neuropathol, London SE5 8AF, England

[6] Reta Lila Weston Inst Neurol Sci, London, England

[7] UCL, London, England

[8] Royal Victoria Infirm, Dept Neurol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

来源：

NEUROLOGY | 2000年 / 55卷 / 12期

关键词：

D O I：

10.1212/WNL.55.12.1918

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alpha synuclein, tau, synphilin, and APOE genotypes were analyzed in patients with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and controls. The predisposing effect of the tau insertion polymorphism to the development of PSP is confirmed. However, no effect of alpha -synuclein, synphilin, or APOE variability on the development of PSP, or of tan, alpha -synuclein, APOE, or synphilin gene variability on the development of MSA, are demonstrated.

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页码：1918 / 1920

页数：3

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