Activation of autoimmune B cells and chronic rejection

被引：19

作者：

Rose, ML ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Harefield Hosp, Harefield, Middx, England

来源：

TRANSPLANTATION | 2005年 / 79卷 / 03期

关键词：

D O I：

10.1097/01.tp.0000153294.38939.5F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Allotransplantation into immumosuppressed individuals results in long-term survival of grafts. However, the grafts are damaged, probably at many stages before, during and after implantation. The hypothesis to be presented is that release of antigens and autoantigens from the chronically damaged graft results in breaking tolerance to self-antigens and an autoimmune response. There is experimental evidence that autoimmune responses following allotransplantation are damaging and cause accelerated graft rejection.

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收藏

页码：S22 / S24

页数：3

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