Phosphoinositide phosphatases in a network of signalling reactions

被引：48

作者：

Blero, Daniel

Payrastre, Bernard

Schurmans, Stephane

Erneux, Christophe

机构：

[1] Free Univ Brussels, Interdisciplinary Res Inst, B-1070 Brussels, Belgium

[2] Hop Erasme, Serv Gastroenterol Med, Brussels, Belgium

[3] IRIBHM, IBMM, B-6041 Gosselies, Belgium

[4] Hop Purpan, INSERM, U563, Dept Oncogene Signalisat Cell Hematopoietiques, F-31059 Toulouse, France

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2007年 / 455卷 / 01期

关键词：

poly-phosphoinositides; inositol 1,4,5-trisphosphate; PTEN; inositol polyphosphate 5-phosphatases; myotubularin; SHIP phosphatases;

D O I：

10.1007/s00424-007-0304-5

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Phosphoinositide phosphatases dephosphorylate the three positions (D-3, 4 and 5) of the inositol ring of the poly-phosphoinositides. They belong to different families of enzymes. The PtdIns(3,4)P-2 4-phosphatase family, the tumour suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), SAC1 domain phosphatases and myotubularins belong to the tyrosine protein phosphatases superfamily. They share the presence of a conserved cysteine residue in the consensus CX5RT/S. Another family consists of the inositol polyphosphate 5-phosphatase isoenzymes. The importance of these phosphoinositide phosphatases in cell regulation is illustrated by multiple examples of their implications in human diseases such as Lowe syndrome, X-linked myotubular myopathy, cancer, diabetes or bacterial infection.

引用

收藏

页码：31 / 44

页数：14

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