Event-related beamforming: A robust method for presurgical functional mapping using MEG

被引:154
作者
Cheyne, Douglas
Bostan, Andreea C.
Gaetz, William
Pang, Elizabeth W.
机构
[1] Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON M5G 1X8, Canada
[2] Hosp Sick Children, Res Inst, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada
[3] Hosp Sick Children, Div Neurol, Toronto, ON M5G 1X8, Canada
[4] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada
[5] Univ Toronto, Dept Pediat, Toronto, ON, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
magnetoencephalography; beamformers; presurgical functional mapping; surgical guidance; magnetic source imaging;
D O I
10.1016/j.clinph.2007.05.064
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: We describe the application of a new spatial filtering technique - event-related beamforming (ERB) - for presurgical functional mapping of primary sensory areas using MEG. This method provides an alternative to equivalent current dipole (ECD) modeling that potentially eliminates problems of intracranial magnetic artifacts due to movement of ferromagnetic materials (e.g., orthodontic braces) or eye movements. Methods: We compared localization results for ERB and ECD localization of primary somatosensory (M20) and auditory (M100) evoked responses in 12 healthy control subjects and four subjects with metallic dental implants. Data were recorded with a 151-channel CTF MEG system using standard presurgical mapping protocols. Results: We found a high level of agreement between the two methods in control subjects (overall localization difference was 5.9 2.2 mm for M20 and 10.4 +/- 5.6 mm for M100). Subjects with dental implants showed severely distorted evoked responses that could not be analyzed using ECD, whereas the ERB method localized sources to expected anatomical locations. Conclusions: MEG functional mapping may be carried out without removal of orthodontic or other metallic implants using event-related beamformer analysis. Significance: Spatial filtering methods can overcome some of the limitations associated with MEG expanding its applicability, particularly in pediatric clinical environments. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1691 / 1704
页数:14
相关论文
共 51 条
[1]   Optimization of an independent component analysis approach for artifact identification and removal in magnetoencephalographic signals [J].
Barbati, G ;
Porcaro, C ;
Zappasodi, F ;
Rossini, PM ;
Tecchio, F .
CLINICAL NEUROPHYSIOLOGY, 2004, 115 (05) :1220-1232
[2]   Correlates of eye blinking as determined by synthetic aperture magnetometry [J].
Bardouille, T. ;
Picton, T. W. ;
Ross, B. .
CLINICAL NEUROPHYSIOLOGY, 2006, 117 (05) :952-958
[3]   Realistic spatial sampling for MEG beamformer images [J].
Barnes, GR ;
Hillebrand, A ;
Fawcett, IP ;
Singh, KD .
HUMAN BRAIN MAPPING, 2004, 23 (02) :120-127
[4]   Maximum-likelihood estimation of low-rank signals for multiepoch MEG/EEG analysis [J].
Baryshnikov, BV ;
Van Veen, BD ;
Wakai, RT .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2004, 51 (11) :1981-1993
[5]  
BAYLESS SJ, 2006, NEUROSCI LETT
[6]   SUPER-RESOLUTION OF UNCORRELATED INTERFERENCE SOURCES BY USING ADAPTIVE ARRAY TECHNIQUES [J].
BORGIOTTI, GV ;
KAPLAN, LJ .
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION, 1979, 27 (06) :842-845
[7]  
BOSTAN A, 2006, P 15 INT C BIOM VANC, P276
[8]   AN INVESTIGATION OF HUMAN CORTICAL EVOKED POTENTIAL UNDER CONDITIONS OF MONAURAL AND BINAURAL STIMULATION [J].
BUTLER, RA ;
KEIDEL, WD ;
SPRENG, M .
ACTA OTO-LARYNGOLOGICA, 1969, 68 (04) :317-&
[9]   Spatiotemporal mapping of cortical activity accompanying voluntary movements using an event-related beamforming approach [J].
Cheyne, D ;
Bakhtazad, L ;
Gaetz, W .
HUMAN BRAIN MAPPING, 2006, 27 (03) :213-229
[10]  
CHEYNE D, 2004, P 14 INT C BIOM, P488