Effects of absorption rate on the pre-systemic chiral inversion of ibuprofen in rabbits

被引：11

作者：

Doki, K ^{[1
]}

Hayakawa, T ^{[1
]}

Lin, WH ^{[1
]}

Yanaguimoto, H ^{[1
]}

Ding, GH ^{[1
]}

Inotsume, N ^{[1
]}

机构：

[1] Hokkaido Coll Pharm, Dept Pharmcol & Therapeut, Otaru, Hokkaido 0470264, Japan

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 2003年 / 55卷 / 08期

关键词：

D O I：

10.1211/0022357021404

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The chiral inversion kinetics of ibuprofen was evaluated after intraduodenal administration of racemic ibuprofen in conventional powder form and sustained-released granules compared with intravenous administration in rabbits. The AUC ratios of the S-(+) and R-(-) enantiomers remained almost constant values with time up to 2 In after administration of sustained-release formulation, while those after administration of the powder increased with time. R-(-) enantiomer to S-(+) enantiomer inversion ratios after intraduodenal administration of the powder form and the sustained-re lease form, and after intravenous injection were calculated to be 1.63, 1.94 and 1.19, respectively, indicating that pharmacological effects may depend on the absorption rate in rabbits.

引用

页码：1091 / 1097

页数：7

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