Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: a review of the protective action of melatonin

被引：14

作者：

Gultekin, Fatih ^{[1
]}

Hicyilmaz, Hicran ^{[1
]}

机构：

[1] Suleyman Demirel Univ, Tip Fak, Sch Med, Dept Biochem, TR-32260 Isparta, Turkey

来源：

ARCHIVES OF TOXICOLOGY | 2007年 / 81卷 / 10期

关键词：

melatonin; kidney; free radical; 2-nitropropane; arsenic; carbon tetrachloride; nitrilotriacetic acid; potassium bromate;

D O I：

10.1007/s00204-007-0242-1

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage.

引用

页码：675 / 681

页数：7

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