Omega-3 fatty acids in the prevention and control of cardiovascular disease

被引:23
作者
López, PM
Ortega, RM [1 ]
机构
[1] Univ Complutense, Fac Farm, Dept Nutr, E-28040 Madrid, Spain
[2] Fdn Jimenez Diaz, Unidad Lipidos, E-28040 Madrid, Spain
关键词
omega-3 fatty acids; cardiovascular disease; epidemiological evidence; mechanisms of action; adverse effects;
D O I
10.1038/sj.ejcn.1601805
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Cardiovascular disease is one of the main causes of death in developed countries. Several factors are involved in its appearance and progress, among which nutrition enjoys a certain protagonism. Until recently, the dietetic criteria for preventing and controlling cardiovascular disease were mainly restrictive (at least in terms of energy and fat intake), but such advice is difficult to follow, and without careful monitoring can lead to deficiencies that might negatively affect quality of life and perhaps even life expectancy. Several investigations show that some components of the lipid fraction of the diet, such as omega-3 fatty acids, are beneficial with respect to cardiovascular disease, and these have become the Centre of much attention. This paper reviews the results of some of these studies and evaluates the benefit of these fatty acids in the prevention of coronary heart disease. The sources of omega-3 fatty acids, their recommended consumption, possible mechanisms of action and potential adverse effects are discussed.
引用
收藏
页码:S22 / S25
页数:4
相关论文
共 24 条
[1]   Blood levels of long-chain n-3 fatty acids and the risk of sudden death. [J].
Albert, CM ;
Campos, H ;
Stampfer, MJ ;
Ridker, PM ;
Manson, JE ;
Willett, WC ;
Ma, J .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (15) :1113-1118
[2]   Fish consumption and risk of sudden cardiac death [J].
Albert, CM ;
Hennekens, CH ;
O'Donnell, CJ ;
Ajani, UA ;
Carey, VJ ;
Willett, WC ;
Ruskin, JN ;
Manson, JE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (01) :23-28
[3]  
*AM HEART ASS, 1995, HEART STROK FACTS 19
[4]  
BRAUNWALD E, 2001, JAMA-J AM MED ASSOC, V285, P2486
[5]  
Carroll DN, 2002, ANN PHARMACOTHER, V36, P1950, DOI 10.1345/aph.1A314
[6]  
Connor WE, 2000, AM J CLIN NUTR, V71, p171S, DOI 10.1093/ajcn/71.1.171S
[7]   Separate and joint effects of marine oil and simvastatin in patients with combined hyperlipidemia [J].
Davidson, MH ;
MacariolaCoad, JR ;
McDonald, AM ;
Maki, KC ;
Hall, HA .
AMERICAN JOURNAL OF CARDIOLOGY, 1997, 80 (06) :797-&
[8]   Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction - Final report of the Lyon Diet Heart Study [J].
de Lorgeril, M ;
Salen, P ;
Martin, JL ;
Monjaud, I ;
Delaye, J ;
Mamelle, N .
CIRCULATION, 1999, 99 (06) :779-785
[9]  
Djoussé L, 2001, AM J CLIN NUTR, V74, P612
[10]  
Eritsland J, 2000, AM J CLIN NUTR, V71, p197S, DOI 10.1093/ajcn/71.1.197S