Near-Infrared-Fluorescence-Enhanced Molecular Imaging of Live Cells on Gold Substrates

被引:76
作者
Hong, Guosong [1 ]
Tabakman, Scott M. [1 ]
Welsher, Kevin [2 ]
Chen, Zhuo [3 ]
Robinson, Joshua T. [1 ]
Wang, Hailiang [1 ]
Zhang, Bo [1 ]
Dai, Hongjie [1 ]
机构
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
[2] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
[3] Hunan Univ, Coll Biol, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
Carbon nanotubes; fluorescence; live-cell imaging; WALLED CARBON NANOTUBES; SINGLE-PARTICLE TRACKING; TRANSPORTERS; DYE;
D O I
10.1002/anie.201100934
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
In the best light: Plasmonic gold substrates were used to image cells by near-infrared fluorescence microscopy. Two fluorophores (single-walled carbon nanotubes (SWNTs) functionalized by the RGD sequence as well as the organic fluorophore IR800) tag cells in two different spectral regions. The fluorescence of SWNTs sandwiched between a cell membrane and a gold film was enhanced relative to the fluorescence observed on a quartz substrate (see picture). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:4644 / 4648
页数:5
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