Mechanisms and Genetics of Antipsychotic-Associated Weight Gain

被引：43

作者：

Balt, S. L. ^{[1
]}

Galloway, G. P. ^{[1
]}

Baggott, M. J. ^{[1
]}

Schwartz, Z. ^{[1
]}

Mendelson, J. ^{[1
]}

机构：

[1] Calif Pacific Med Ctr, Res Inst, Addict Pharmacol Res Lab, San Francisco, CA 94120 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 90卷 / 01期

关键词：

ATYPICAL ANTIPSYCHOTICS; OBESITY; LEPTIN; SCHIZOPHRENIA; MANAGEMENT; ACTIVATION; DISORDER; DRUGS;

D O I：

10.1038/clpt.2011.97

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Antipsychotic medications, which comprise one of the most widely prescribed medication classes, have proven effective in many psychiatric conditions. However, these agents can also be associated with obesity and other metabolic abnormalities, the mechanisms of which have been partially elucidated. We review here the current state of knowledge of the effects of these medications on weight and appetite, as well as genetic markers that may help predict weight gain and prevent the undesirable cardiometabolic effects of these agents.

引用

页码：179 / 183

页数：5

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