Blood:air partition coefficients of individual and mixtures of trihalomethanes

被引：7

作者：

Béliveau, M ^{[1
]}

Charest-Tardif, G ^{[1
]}

Krishnan, K ^{[1
]}

机构：

[1] Univ Montreal, Fac Med, Dept Sante Environm & Sante Travail, Montreal, PQ H3C 3J7, Canada

来源：

CHEMOSPHERE | 2001年 / 44卷 / 03期

关键词：

trihalomethanes; blood : air partition coefficients; mixtures; PBPK modeling;

D O I：

10.1016/S0045-6535(00)00203-4

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The objective of the present study was to determine the rat blood:air partition coefficients (P-b:a) Of chloroform, bromodichloromethane, dibromochloromethane and bromoform present in vitro individually or as mixtures. The experimentally determined P-b:a Of chloroform, bromodichloromethane, dibromochloromethane and bromoform present individually corresponded to (mean +/- SD, n = 8) 21.3 +/- 1.8, 41.8 +/- 6.2, 97.5 +/- 4.1, and 187 +/- 7.4, respectively. The P-b:a Of these trihalomethanes (THMs) showed a decreasing trend during mixed in vitro exposures to 0.138 +/- 0.002 or 0.273 +/- 0.002 mu mol of each of the four THMs. In general, the P-b:a determined during mixed exposures differed by less than or equal to 15% of the average P-b:a determined for THMs present individually. The results of this study suggest that an alteration of P-b:a Of the individual THMs is unlikely to occur at the blood concentrations of THMs observed during mixed exposures in rats. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：377 / 381

页数：5

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