Linoleic acid peroxidation - the dominant lipid peroxidation process in low density lipoprotein - and its relationship to chronic diseases

被引：186

作者：

Spiteller, G ^{[1
]}

机构：

[1] Univ Bayreuth, Lehrstuhl Organ Chem 1, D-95440 Bayreuth, Germany

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1998年 / 95卷 / 02期

关键词：

lipid peroxidation; linoleic acid peroxidation; hydroxy acids; epoxides; aldehydes; mass spectrometry; atherosclerosis; antioxidants;

D O I：

10.1016/S0009-3084(98)00091-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Modern separation and identification methods enable detailed insight in lipid peroxidation (LPO) processes. The following deductions can be made: (1) Cell injury activates enzymes: lipoxygenases generate lipid hydroperoxides (LOOHs), proteases liberate Fe ions-these two processes are prerequisites to produce radicals. (2) Radicals attack any activated CH2-group of polyunsaturated fatty acids (PUFAs) with about a similar probability. Since linoleic acid (LA) is the most abundant PUFA in mammals, its LPO products dominate. (3) LOOHs are easily reduced in biological surroundings to corresponding hydroxy acids (LOHs). LOHs derived from LA, hydroxyoctadecadienoic acids (HODEs), surmount other markers of LPO. HODEs are of high physiological relevance. (4) In some diseases characterized by inflammation or cell injury HODEs are present in low density lipoproteins (LDL) at 10-100 higher concentration, compared to LDL from healthy individuals. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：105 / 162

页数：58

共 539 条

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PULSE RADIOLYSIS STUDIES ON OXIDATION OF ORGANIC RADICALS IN AQUEOUS SOLUTION [J].