COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers What Is the Evidence?

被引:291
作者
Patel, Ankit B. [1 ]
Verma, Ashish [1 ]
机构
[1] Brigham & Womens Hosp, Renal Div, 75 Francis St, Boston, MA 02115 USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2020年 / 323卷 / 18期
关键词
ACE2;
D O I
10.1001/jama.2020.4812
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
This Viewpoint reviews the pathophysiological and observational basis for speculating that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) might worsen clinical outcomes for patients with COVID-19, and summarizes guidance from specialty societies to continue the drugs in patients who need them pending more definitive evidence of harm.
引用
收藏
页码:1769 / 1770
页数:2
相关论文
共 9 条
[1]
Angiotensin converting enzyme Inhibitors and angiotensin Receptor Blockers, HFSA ACC AHA STAT AD
[2]
European Society of Cardiology, 2020, Position statement of the ESC Council on Hypertension on ACE-inhibitors and angiotensin receptor blockers.
[3]
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome [J].
Khan, Akram ;
Benthin, Cody ;
Zeno, Brian ;
Albertson, Timothy E. ;
Boyd, John ;
Christie, Jason D. ;
Hall, Richard ;
Poirier, Germain ;
Ronco, Juan J. ;
Tidswell, Mark ;
Hardes, Kelly ;
Powley, William M. ;
Wright, Tracey J. ;
Siederer, Sarah K. ;
Fairman, David A. ;
Lipson, David A. ;
Bayliffe, Andrew I. ;
Lazaar, Aili L. .
CRITICAL CARE, 2017, 21
[4]
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury [J].
Kuba, K ;
Imai, Y ;
Rao, SA ;
Gao, H ;
Guo, F ;
Guan, B ;
Huan, Y ;
Yang, P ;
Zhang, YL ;
Deng, W ;
Bao, LL ;
Zhang, BL ;
Liu, G ;
Wang, Z ;
Chappell, M ;
Liu, YX ;
Zheng, DX ;
Leibbrandt, A ;
Wada, T ;
Slutsky, AS ;
Liu, DP ;
Qin, CA ;
Jiang, CY ;
Penninger, JM .
NATURE MEDICINE, 2005, 11 (08) :875-879
[5]
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism [J].
Rice, GI ;
Thomas, DA ;
Grant, PJ ;
Turner, AJ ;
Hooper, NM .
BIOCHEMICAL JOURNAL, 2004, 383 :45-51
[6]
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China [J].
Wu, Chaomin ;
Chen, Xiaoyan ;
Cai, Yanping ;
Xia, Jia'an ;
Zhou, Xing ;
Xu, Sha ;
Huang, Hanping ;
Zhang, Li ;
Zhou, Xia ;
Du, Chunling ;
Zhang, Yuye ;
Song, Juan ;
Wang, Sijiao ;
Chao, Yencheng ;
Yang, Zeyong ;
Xu, Jie ;
Zhou, Xin ;
Chen, Dechang ;
Xiong, Weining ;
Xu, Lei ;
Zhou, Feng ;
Jiang, Jinjun ;
Bai, Chunxue ;
Zheng, Junhua ;
Song, Yuanlin .
JAMA INTERNAL MEDICINE, 2020, 180 (07) :934-943
[7]
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention [J].
Wu, Zunyou ;
McGoogan, Jennifer M. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (13) :1239-1242
[8]
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study [J].
Zhou, Fei ;
Yu, Ting ;
Du, Ronghui ;
Fan, Guohui ;
Liu, Ying ;
Liu, Zhibo ;
Xiang, Jie ;
Wang, Yeming ;
Song, Bin ;
Gu, Xiaoying ;
Guan, Lulu ;
Wei, Yuan ;
Li, Hui ;
Wu, Xudong ;
Xu, Jiuyang ;
Tu, Shengjin ;
Zhang, Yi ;
Chen, Hua ;
Cao, Bin .
LANCET, 2020, 395 (10229) :1054-1062
[9]
A pneumonia outbreak associated with a new coronavirus of probable bat origin [J].
Zhou, Peng ;
Yang, Xing-Lou ;
Wang, Xian-Guang ;
Hu, Ben ;
Zhang, Lei ;
Zhang, Wei ;
Si, Hao-Rui ;
Zhu, Yan ;
Li, Bei ;
Huang, Chao-Lin ;
Chen, Hui-Dong ;
Chen, Jing ;
Luo, Yun ;
Guo, Hua ;
Jiang, Ren-Di ;
Liu, Mei-Qin ;
Chen, Ying ;
Shen, Xu-Rui ;
Wang, Xi ;
Zheng, Xiao-Shuang ;
Zhao, Kai ;
Chen, Quan-Jiao ;
Deng, Fei ;
Liu, Lin-Lin ;
Yan, Bing ;
Zhan, Fa-Xian ;
Wang, Yan-Yi ;
Xiao, Geng-Fu ;
Shi, Zheng-Li .
NATURE, 2020, 579 (7798) :270-+