Cytotoxic diterpenoids from two lianas from the Suriname rainforest

被引：27

作者：

Adou, E

Williams, RB

Schilling, JK

Malone, S

Meyer, J

Wisse, JH

Frederik, D

Koese, D

Werkhoven, MCM

Snipes, CE

Werk, TL

Kingston, DGI

机构：

[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[2] Conservat Int Suriname, Paramaribo, Suriname

[3] Bedriff Geneesmiddelen Voorziening Suriname, Geyersvlijt, Suriname

[4] Natl Herbarium Suriname, Paramaribo, Suriname

[5] Dow AgroSci, Indianapolis, IN 46268 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 21期

关键词：

diterpenoids; icacinaceae; phytopathogen; cytotoxicity; humirianthol; annonalide;

D O I：

10.1016/j.bmc.2005.07.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioassay-guided fractionation of the MeOH and EtOAc fractions of extracts of two lianas collected in Suriname has led to the isolation of five new diterpenoids, humirianthone 1, 1-hydroxy-humirianthone 2, 15R-humirianthol 3, patagonol 4, and patagonal 5, and the five known diterpenoids, humirianthol 7, annonalide 8, acrenol 9, icacinol 10, and the oxidized annonalide 11. All 10 diterpenoids showed cytotoxic activity against the A2780 human ovarian cancer cell line, and compounds 1, 3, 8, and 9 also showed activity against phytopathogenic fungi. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6009 / 6014

页数：6

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