Host signal transduction and endocytosis of Campylobacter jejuni

被引:97
作者
Wooldridge, KG
Williams, PH
Ketley, JM
机构
[1] UNIV LEICESTER,DEPT GENET,LEICESTER LE1 7RH,LEICS,ENGLAND
[2] UNIV LEICESTER,DEPT MICROBIOL & IMMUNOL,LEICESTER LE1 7RH,LEICS,ENGLAND
基金
英国惠康基金;
关键词
Campylobacter jejuni; invasion; endocytosis; caveolae; PI-3; kinase;
D O I
10.1006/mpat.1996.0063
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Caveolae are plasma membrane invaginations found in a variety of mammalian cells and are implicated in clathrin-independent endocytosis and signal transduction. Here we show that pretreatment of Caco-2 cell monolayers with filipin III, which disrupts caveolae by chelating cholesterol, significantly reduces the ability of Campylobacter jejuni to enter these cells. Furthermore inhibitors of host protein tyrosine phosphorylation, the phosphatidylinositol-3 kinase (Pl 3-kinase) inhibitor wortmannin, and cholera toxin, all significantly reduced invasion of Caco-2 cells by C. jejuni. (C) 1996 Academic Press Limited.
引用
收藏
页码:299 / 305
页数:7
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