Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications

被引：112

作者：

Chen, Chi-Yuan ^{[1
]}

Lin, Chin-Yu ^{[1
]}

Chen, Guan-Yu ^{[1
]}

Hu, Yu-Chen ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan

来源：

BIOTECHNOLOGY ADVANCES | 2011年 / 29卷 / 06期

关键词：

Baculovirus; Vaccine; Immune responses; Tissue engineering; Cancer therapy; Antiviral therapy; MESENCHYMAL STEM-CELLS; ROTATING-SHAFT BIOREACTOR; GREEN FLUORESCENT PROTEIN; RETRACTED ARTICLE. SEE; AVIAN INFLUENZA-VIRUS; SWINE-FEVER VIRUS; MAMMALIAN-CELLS; RECOMBINANT BACULOVIRUS; SURFACE DISPLAY; IMMUNE-RESPONSES;

D O I：

10.1016/j.biotechadv.2011.04.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity, low cytotoxicity and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has gained explosive popularity as a gene delivery vector for a wide variety of applications. This article extensively reviews the recent understandings of the molecular mechanisms pertinent to baculovirus entry and cellular responses, and covers the latest advances in the vector improvements and applications, with special emphasis on antiviral therapy, cancer therapy, regenerative medicine and vaccine. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：618 / 631

页数：14

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