Development and evolution of ROR?t plus cells in a microbe's world

被引：48

作者：

Eberl, Gerard ^{[1
,2
]}

机构：

[1] Inst Pasteur, Lymphoid Tissue Dev Unit, F-75724 Paris, France

[2] CNRS, URA 1961, Paris, France

来源：

IMMUNOLOGICAL REVIEWS | 2012年 / 245卷

关键词：

ROR?t; Th17; cells; innate lymphoid cells; IL-17; IL-22; symbiotic microbiota; DELTA-T-CELLS; NATURAL-KILLER-CELLS; INFLAMMATORY-BOWEL-DISEASE; INNATE LYMPHOID-CELLS; TISSUE-INDUCER CELLS; LYMPHOTOXIN-BETA-RECEPTOR; RETINOIC ACID RECEPTOR; INVARIANT NKT CELLS; GAMMA-T; ORPHAN RECEPTOR;

D O I：

10.1111/j.1600-065X.2011.01071.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The nuclear hormone receptor retinoid-related orphan receptor ?t (ROR?t) induces a pro-inflammatory program in lymphoid cells, culminating in the expression of interleukin-6 (IL-6), IL-17, IL-22, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor. During ontogeny, the first type of cells expressing ROR?t are lymphoid tissue inducer cells, a type of innate lymphoid cell (ILC) generated in mammalian fetuses to induce the development of lymph nodes and Peyers patches. After birth, ROR?t+ ILCs and ROR?t+ T cells are involved in the defense of epithelial surfaces against extracellular microbes and play an important role in the intestinal homeostasis with symbiotic microbiota. The development and evolution of ROR?t+ cells is intimately associated with the construction of a stable hostmicrobe interface.

引用

页码：177 / 188

页数：12

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