Genome-Wide Searches for Bipolar Disorder Genes

被引：11

作者：

Alsabban, Shaza ^{[1
]}

Rivera, Margarita ^{[1
]}

McGuffin, Peter ^{[1
]}

机构：

[1] Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat, London SE5 8AF, England

来源：

CURRENT PSYCHIATRY REPORTS | 2011年 / 13卷 / 06期

基金：

英国医学研究理事会;

关键词：

Bipolar disorder; Genes; Whole-genome linkage; Whole-genome association; Copy number variants; CNV; Pathway analysis; MAJOR AFFECTIVE-DISORDER; SUSCEPTIBILITY LOCI; DARIERS-DISEASE; LINKAGE SCAN; CHROMOSOME; 12Q23-Q24; FAMILIAL COSEGREGATION; DEPRESSIVE DISORDER; ISOLATED POPULATION; SUGGESTIVE LINKAGE; ASSOCIATION DATA;

D O I：

10.1007/s11920-011-0226-y

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Whole-genome linkage and association studies of bipolar disorder are beginning to provide some compelling evidence for the involvement of several chromosomal regions and susceptibility genes in the pathogenesis of bipolar disorder. Developments in genotyping technology and efforts to combine data from different studies have helped in identifying chromosomes 6q16-q25, 13q, and 16p12 as probable susceptibility loci for bipolar disorder and confirmed CACNA1C and ANK3 as susceptibility genes for bipolar disorder. However, a lack of replication is still apparent in the literature. New studies focusing on copy number variants as well as new analytical approaches utilizing pathway analysis offer a new direction in the study of the genetics of bipolar disorder.

引用

页码：522 / 527

页数：6

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