COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome

被引：255

作者：

Gothelf, D

Eliez, S

Thompson, T

Hinard, C

Penniman, L

Feinstein, C

Kwon, H

Jin, ST

Jo, B

Antonarakis, SE

Morris, MA

Reiss, AL

机构：

[1] Stanford Univ, Sch Med, Ctr Interdisciplinary Brain Sci Res, Stanford, CA 94305 USA

[2] Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel

[3] Univ Geneva, Sch Med, Dept Psychiat, CH-1206 Geneva, Switzerland

[4] Univ Hosp Geneva, Med Genet Serv, CH-1211 Geneva, Switzerland

[5] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98104 USA

[6] Ctr Med Univ Geneva, Univ Med Sch, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 11期

关键词：

D O I：

10.1038/nn1572

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although schizophrenia is strongly hereditary, there are limited data regarding biological risk factors and pathophysiological processes. In this longitudinal study of adolescents with 22q11.2 deletion syndrome, we identified the catechol-O-methyltransferase low-activity allele (COMTL) as a risk factor for decline in prefrontal cortical volume and cognition, as well as for the consequent development of psychotic symptoms during adolescence. The 22q11.2 deletion syndrome is a promising model for identifying biomarkers related to the development of schizophrenia.

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页码：1500 / 1502

页数：3

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