N-terminal pro-B-type natriuretic peptide predicts significant coronary artery lesion in the unstable angina patients with normal electrocardiogram, echocardiogram, and cardiac enzymes

被引：17

作者：

Hong, SN ^{[1
]}

Yoon, NS ^{[1
]}

Ahn, Y ^{[1
]}

Lim, SY ^{[1
]}

Kim, YS ^{[1
]}

Yun, KH ^{[1
]}

Kang, DK ^{[1
]}

Lee, SH ^{[1
]}

Lee, YS ^{[1
]}

Kim, KH ^{[1
]}

Son, IS ^{[1
]}

Hong, YJ ^{[1
]}

Park, HW ^{[1
]}

Kim, JH ^{[1
]}

Jeong, MH ^{[1
]}

Cho, JG ^{[1
]}

Park, JC ^{[1
]}

Kang, JC ^{[1
]}

机构：

[1] Chonnam Natl Univ, Res Inst Med Sci, Ctr Heart, Dept Cardiovasc Med,Chonnam Natl Univ Hosp, Kwangju 501757, South Korea

来源：

CIRCULATION JOURNAL | 2005年 / 69卷 / 12期

关键词：

coronary artery disease; NT-proBNP; unstable angina;

D O I：

10.1253/circj.69.1472

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are not specific for ventricular dysfunction and other cardiac processes, such as myocardial ischernia, may also cause elevation of these markers. Methods and Results To determine whether elevation of NT-proBNP without elevation of cardiac specific markers can predict coronary artery disease (CAD), the serum level of NT-proBNP was measured in 161 patients with unstable angina (61.0 +/- 8.1 years, male 54.0%) with normal ventricular function (left ventricular ejection fraction > 55% and no regional wall motion abnormality by echocardiography) and normal troponin I level (< 0.05 ng/ml). In these patients, levels of C-reactive protein and myoglobin were normal and none had Q wave on electrocardiographic (ECG). The NT-proBNP level was higher in patients with CAD (n=74) than in patients without CAD (n=87) (173.1 +/- 231.6 vs 68.1 +/- 62.5pg/ml, p < 0.001). At the standard cut-off point of > 200pg/ml, elevated NT-proBNP level shows high probability of CAD (odds ratio, 10.1; 95% confidence interval, 2.6-38.7, p=0.001). The NT-proBNP level positively correlated with the extent of CAD (r=0.329, p=0.001). In multivariate analysis, the NT-proBNP was an independent predictor of CAD. Conclusion These results suggested that NT-proBNP is a useful screening test for CAD in the unstable angina patients with normal ECG, echocardiogram and cardiac enzyme levels.

引用

页码：1472 / 1476

页数：5

共 23 条

[1] Plasma amino-terminal pro-brain natriuretic peptide levels in subjects presenting to the Emergency Department with suspected acute coronary syndrome: possible role in selecting patients for follow up? [J].