Comparison of multi-lineage cells from human adipose tissue and bone marrow

被引：909

作者：

De Ugarte, DA

Morizono, K

Elbarbary, A

Alfonso, Z

Zuk, PA

Zhu, M

Dragoo, JL

Ashjian, P

Thomas, B

Benhaim, P

Chen, I

Fraser, J

Hedrick, MH

机构：

[1] Univ Calif Los Angeles, Div Plast & Reconstruct Surg, Ctr Hlth Sci, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Regenerat Bioengn & Repair Lab, Dept Surg, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Sch Med, Regenerat Bioengn & Repair Lab, Dept Orthopaed, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Sch Med, Div Hematol & Oncol, Dept Med, Los Angeles, CA USA

[5] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Med, Los Angeles, CA 90024 USA

来源：

CELLS TISSUES ORGANS | 2003年 / 174卷 / 03期

关键词：

mesenchymal stem cell; lipoaspirate; processed lipoaspirate cells; adipose tissue;

D O I：

10.1159/000071150

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Our laboratory has recently characterized a population of cells from adipose tissue, termed processed lipoaspirate (PLA) cells, which have multi-lineage potential similar to bone-marrow-derived mesenchymal stem cells (MSCs). This study is the first comparison of PLA cells and MSCs isolated from the same patient. No significant differences were observed for yield of adherent stromal cells, growth kinetics, cell senescence, multi-lineage differentiation capacity, and gene transduction efficiency. Adipose tissue is an abundant and easily procured source of PLA cells, which have a potential like MSCs for use in tissue-engineering applications and as gene delivery vehicles. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：101 / 109

页数：9

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