HPLC fingerprinting and estimation of the bioactive components of Clutia richardiana L. as a potential hypoglycemic herbal tea

被引:13
作者
Abourashed, EA
Ganzera, M
Khan, IA [1 ]
Khan, S
Mossa, JS
El-Feraly, FS
机构
[1] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA
[2] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh, Saudi Arabia
关键词
Clutia/Cluytia richardiana; Euphorbiaccae; HPLC fingerprinting; cytotoxicity; traditional medicine; hypoglycemic herb;
D O I
10.1002/ptr.1223
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Clutia richardiana L. is a traditional medicinal herb with demonstrated hypoglycemic effects. An HPLC method (Luna(R) C-18 column, gradient elution, UV detection at 220 nm) has been utilizer to determine the levels of the major diterpenes of C. richardiana in extracts obtained by using three different solvents. Extraction with the organic solvents methanol and acetonitrile was more efficient than aqueous extraction with hot water, but nine markers could be detected equally in all extracts. The aqueous extract was non-toxic against a number of human cell lines, which is a promising indication for its use as a safe and effective antidiabetic herbal preparation. Copyright (C) 2003 John Wiley Sons, Ltd.
引用
收藏
页码:657 / 660
页数:4
相关论文
共 10 条
[1]   TOXICITY DETERMINED INVITRO BY MORPHOLOGICAL ALTERATIONS AND NEUTRAL RED ABSORPTION [J].
BORENFREUND, E ;
PUERNER, JA .
TOXICOLOGY LETTERS, 1985, 24 (2-3) :119-124
[2]   Catalytic inhibition of topoisomerase IIα by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica [J].
Furbacher, TR ;
Gunatilaka, AAL .
JOURNAL OF NATURAL PRODUCTS, 2001, 64 (10) :1294-1296
[3]  
López-Lázaro M, 2001, ANTICANCER RES, V21, P3493
[4]  
MOSSA J S, 1988, International Journal of Crude Drug Research, V26, P81
[5]   NOVEL 6,7-SECO-6,11-CYCLOLABDANE DITERPENES FROM CLUYTIA-RICHARDIANA [J].
MOSSA, JS ;
CASSADY, JM ;
KOZLOWSKI, JF ;
ZENNIE, TM ;
ANTOUN, MD ;
PELLECHIA, MG ;
MCKENZIE, AT ;
BYRN, SR .
TETRAHEDRON LETTERS, 1988, 29 (30) :3627-3630
[6]   Five new modified 6,7-secolabdane diterpenoids from Cluytia richardiana [J].
Mossa, JS ;
Muhammad, I ;
AlYahya, MA ;
Mirza, HH ;
ElFeraly, FS ;
McPhail, AT .
JOURNAL OF NATURAL PRODUCTS, 1996, 59 (03) :224-231
[7]   SAUDIN, A HYPOGLYCEMIC DITERPENOID WITH A NOVEL 6,7-SECOLABDANE CARBON SKELETON, FROM CLUYTIA-RICHARDIANA [J].
MOSSA, JS ;
CASSADY, JM ;
ANTOUN, MD ;
BYRN, SR ;
MCKENZIE, AT ;
KOZLOWSKI, JF ;
MAIN, P .
JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (06) :916-918
[8]   MODIFIED LABDANE DITERPENOIDS FROM CLUYTIA-RICHARDIANA [J].
MUHAMMAD, I ;
MOSSA, JS ;
ALYAHYA, MA ;
MIRZA, HH ;
ELFERALY, FS ;
MCPHAIL, AT .
PHYTOCHEMISTRY, 1994, 37 (05) :1377-1381
[9]   NEW MODIFIED LABDANE DITERPENOIDS FROM CLUYTIA-RICHARDIANA [J].
MUHAMMAD, I ;
MOSSA, JS ;
ALYAHYA, MA ;
MIRZA, HH ;
ELFERALY, FS ;
MCPHAIL, AT .
JOURNAL OF NATURAL PRODUCTS, 1994, 57 (02) :248-255
[10]   Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha [J].
Muhammad, I ;
Dunbar, DC ;
Takamatsu, S ;
Walker, LA ;
Clark, AM .
JOURNAL OF NATURAL PRODUCTS, 2001, 64 (05) :559-562