A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways

被引：66

作者：

Al-Jarallah, Aishah

Trigatti, Bernardo L. ^{[1
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8L 2X2, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2010年 / 1801卷 / 12期

基金：

加拿大健康研究院;

关键词：

HDL; SR-BI; Sphingosine-1-phosphate; S1PR; Signaling; Caveolae; Cholesterol; Atheroprotection; NITRIC-OXIDE SYNTHASE; REVERSE CHOLESTEROL TRANSPORT; DOUBLE-KNOCKOUT MICE; ATHEROSCLEROTIC LESION DEVELOPMENT; CORONARY-HEART-DISEASE; E-DEFICIENT MICE; MICROVILLAR CHANNEL FORMATION; ENDOTHELIAL NO SYNTHASE; SELECTIVE LIPID UPTAKE; GROWTH-FACTOR RECEPTOR;

D O I：

10.1016/j.bbalip.2010.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

High density lipoprotein (HDL) levels are inversely proportional to the risk of coronary heart disease. HDL mediates various anti-atherogenic pathways including reverse cholesterol transport from cells of the arterial wall to the liver and steroidogenic tissues. In addition HDL activates various intracellular signaling events that confer atheroprotection. The HDL receptor, scavenger receptor class B type I (SR-BI) has been implicated directly and indirectly in HDL induced signaling. The aim of this review is to summarize the role of SR-BI in HDL induced signaling in the vasculature. (C) 2010 Elsevier B.V. All rights reserved.

引用

收藏

页码：1239 / 1248

页数：10

相关论文

共 189 条

[1]

Identification of scavenger receptor SR-BI as a high density lipoprotein receptor [J].

Acton, S ;

Rigotti, A ;

Landschulz, KT ;

Xu, SZ ;

Hobbs, HH ;

Krieger, M .

SCIENCE, 1996, 271 (5248) :518-520

[2]

ACTON SL, 1994, J BIOL CHEM, V269, P21003

[3]

Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice [J].

Arai, T ;

Rinninger, F ;

Varban, L ;

Fairchild-Huntress, V ;

Liang, CP ;

Chen, WG ;

Seo, T ;

Deckelbaum, R ;

Huszar, D ;

Tall, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :12050-12055

[4]

Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene [J].

Arai, T ;

Wang, N ;

Bezouevski, M ;

Welch, C ;

Tall, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (04) :2366-2371

[5]

Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling [J].

Assanasen, C ;

Mineo, C ;

Seetharam, D ;

Yuhanna, IS ;

Marcel, YL ;

Connelly, MA ;

Williams, DL ;

de la Llera-Moya, M ;

Shaul, PW ;

Silver, DL .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (04) :969-977

[6]

High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport [J].

Assmann, G ;

Schulte, H ;

vonEckardstein, A ;

Huang, YD .

ATHEROSCLEROSIS, 1996, 124 :S11-S20

[7]

2-DIMENSIONAL ELECTROPHORESIS OF PLASMA-LIPOPROTEINS - RECOGNITION OF NEW APO-A-I-CONTAINING SUBPOPULATIONS [J].

ASZTALOS, BF ;

SLOOP, CH ;

WONG, L ;

ROHEIM, PS .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1169 (03) :291-300

[8]

Serum amyloid a binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases [J].

Baranova, IN ;

Vishnyakova, TG ;

Bocharov, AV ;

Kurlander, R ;

Chen, ZG ;

Kimelman, ML ;

Remaley, AT ;

Csako, G ;

Thomas, F ;

Eggerman, TL ;

Patterson, AP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (09) :8031-8040

[9]

BARR DP, 1951, AM J MED, V11, P480, DOI 10.1016/0002-9343(51)90183-0

[10]

High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions [J].

Barter, P ;

Kastelein, J ;

Nunn, A ;

Hobbs, R .

ATHEROSCLEROSIS, 2003, 168 (02) :195-211

← 1 2 3 4 5 6 7 8 9 10 →