HIV-1 X4/R5 co-receptor in viral reservoir during suppressive HAART

被引：30

作者：

Soulie, Cathia ^{[1
]}

Marcelin, Anne-Genevieve

Ghosn, Jade

Amellal, Bahia

Assoumou, Lambert

Lambert, Sidonie

Duvivier, Claudine

Costagliola, Dominique

Katlama, Christine

Calvez, Vincent

机构：

[1] Univ Paris 06, Pitie Salpetriere Hosp, Dept Virol, EA2387, Paris, France

[2] Univ Paris 06, Pitie Salpetriere Hosp, Dept Infect Dis, Paris, France

[3] Univ Paris 06, INSERM, UMR720, Paris, France

来源：

AIDS | 2007年 / 21卷 / 16期

关键词：

D O I：

10.1097/QAD.0b013e3282f0e3d0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As immune recovery during HAART is mainly caused by the expansion of X4-naive cells, we studied the evolution of HIV tropism in the reservoir of 34 patients receiving 48 weeks of HAART. No change in virus tropism was observed over time, but patients with X4 viruses had higher HIV-1 proviral DNA levels than patients with R5 viruses. This suggests that CCR5 antagonist activity should not be compromised in patients harbouring R5 viruses before starting HAART.

引用

页码：2243 / 2245

页数：3

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