Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene

被引：24

作者：

Hosaka, S

Kawa, S

Aoki, Y

Tanaka, E

Yoshizawa, K

Karasawa, Y

Hosaka, N

机构：

[1] Shinshu Univ, Sch Med, Dept Internal Med 2, Nagano 3908621, Japan

[2] Shinshu Univ, Sch Med, Dept Lab Med, Nagano 3908621, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2001年 / 39卷 / 06期

关键词：

caffeine; hepatocarcinogenesis inhibition; ACI rats; 2-acetylaminofluorene;

D O I：

10.1016/S0278-6915(00)00175-7

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The inhibitory effects of caffeine have been demonstrated on the development of various organs in animals. The purpose of the present study was to examine the inhibitory effect of caffeine on hepatocarcinogenesis and to determine the responsive dose of caffeine on hepatocarcinogenesis in young male ACI rats. Animals given a diet containing 2-acetylaminofluorene (2-AAF) for 12 weeks and then a basal diet and tap water containing caffeine for 18 weeks showed statistically significant decreases in the incidence. multiplicity (the number of hepatic tumors per rat) and histological grade compared with rats fed a diet containing carcinogen for 12 weeks followed by tap water alone. Dose-dependent inhibition of hepatocarcinogenesis by caffeine a ns also seen. The inhibitory effect of caffeine on hepatocarcinogenesis in rats was found when caffeine was administered during the initiation phase. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：557 / 561

页数：5

共 39 条

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