Resting Heart Rate: Risk Indicator and Emerging Risk Factor in Cardiovascular Disease

被引：225

作者：

Boehm, Michael ^{[1
]}

Reil, Jan-Christian ^{[1
]}

Deedwania, Prakash ^{[2
]}

Kim, Jae B. ^{[3
]}

Borer, Jeffrey S. ^{[4
]}

机构：

[1] Univ Klinikum Saarlandes, Innere Med Klin 3, DE-66424 Homburg, Germany

[2] Univ Calif San Francisco, Fresno, CA USA

[3] Amgen Inc, Thousand Oaks, CA 91320 USA

[4] Cornell Univ, Weill Med Coll, New York, NY 10021 USA

来源：

AMERICAN JOURNAL OF MEDICINE | 2015年 / 128卷 / 03期

关键词：

Angina; Heart failure; Heart rate; Ivabradine; PLACEBO-CONTROLLED TRIAL; CORONARY-ARTERY-DISEASE; VENTRICULAR SYSTOLIC DYSFUNCTION; CURRENT INHIBITOR IVABRADINE; MULTIPLE ORGAN DYSFUNCTION; FORCE-FREQUENCY-RELATIONSHIP; PRESERVED EJECTION FRACTION; CRITICALLY-ILL PATIENTS; F-CHANNEL INHIBITION; QUALITY-OF-LIFE;

D O I：

10.1016/j.amjmed.2014.09.016

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Resting heart rate is central to cardiac output and is influenced by changes occurring in numerous diseases. It predicts longevity and cardiovascular diseases, and current evidence suggests that it is also an important marker of outcome in cardiovascular disease, including heart failure. Beta-blockers improve outcomes in heart failure; however, they have effects outside reducing heart rate. Ivabradine has demonstrated efficacy in reducing rehospitalizations and mortality in heart failure and in improving exercise tolerance and reducing angina attacks in patients with coronary artery disease, whereas selective heart rate reduction may also prove to be beneficial in therapeutic areas outside those in which ivabradine has already demonstrated clinical efficacy. This review provides an update on the associations between heart rate and cardiovascular outcomes in various conditions, the experimental effects of heart rate reduction with ivabradine, and the potential new indications in cardiovascular disease. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：219 / 228

页数：10

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