3-[123I]iodo-α-methyl-L-tyrosine transport and 4F2 antigen expression in human glioma cells

被引：12

作者：

Langen, KJ ^{[1
]}

Bonnie, R

Mühlensiepen, H

Jansen, P

Bröer, S

Holschbach, M

Coenen, HH

机构：

[1] Forschungszentrum Julich, Res Ctr, Inst Med, D-52425 Julich, Germany

[2] Forschungszentrum Julich, Res Ctr, Cent Inst Appl Math, D-52425 Julich, Germany

[3] Forschungszentrum Julich, Res Ctr, Inst Nucl Chem, D-52425 Julich, Germany

[4] Univ Tubingen, Inst Physiol, D-72076 Tubingen, Germany

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2001年 / 28卷 / 01期

关键词：

amino acids; 3-[I-123]iodo-alpha-methyl-L-tyrosine; glioma cells; 4F2; antigen; proliferation;

D O I：

10.1016/S0969-8051(00)00178-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

3[I-123]iodo-alpha -methyl-L-tyrosine is a tracer of amino acid transport in brain tumors using single-photon emission-computed tomography and predominantly transported by amino acid transport system L. The 4F2 antigen has been identified to be linked to system L-like transport and is assumed to be a part of the transporter protein. We demonstrated that system L-mediated transport of IMT and 4F2 antigen expression are dependent on proliferation rate of human glioma cells and significantly correlated with each other. (C) 2001 Elsevier Science Inc, All rights reserved.

引用

页码：5 / 11

页数：7

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