Enantioselective alkynylation of ketones catalyzed by Zn(salen) complexes

被引：189

作者：

Cozzi, PG ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 25期

关键词：

alkynes; asymmetric catalysis; ketones; salen; tertiary alcohols;

D O I：

10.1002/anie.200351230

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The new frontier in asymmetric catalysis is the selective formation of quaternary stereocenters. The enantioselective addition of nucleophiles to ketones is a particular challenge. Readily prepared Zn(salen) complexes promote the straightforward synthesis of tertiary alcohols from commercially available starting materials (see scheme), thus allowing the preparation of functionalizable chiral building blocks in a catalytic enantioselective procedure that shows broad scope.

引用

页码：2895 / 2898

页数：4

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