Chronic nervous-system effects of long-term occupational exposure to DDT

被引：84

作者：

de Joode, BV

Wesseling, C

Kromhout, H

Monge, P

García, M

Mergler, D

机构：

[1] Univ Nacl, Cent Amer Inst Studies Tox Subst IRET, Heredia, Costa Rica

[2] Univ Utrecht, Envrionm & Occupat Hlth Grp, Inst Risk Assessment Sci, Utrecht, Netherlands

[3] RECOPE, Dept Occupat Hlth, Cartago, Costa Rica

[4] Univ Quebec, Ctr Etud Interact Biol Entre Sante & Environm, Montreal, PQ H3C 3P8, Canada

来源：

LANCET | 2001年 / 357卷 / 9261期

关键词：

D O I：

10.1016/S0140-6736(00)04249-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dichlorodiphenyttrichloroethane (DDT) is a compound with moderate toxicity that is judged to be safe for occupational use, although little is known about its long-term effects on the human nervous system. We investigated chronic nervous-system effects of long-term occupational exposure to DDT by comparing the neurobehavioural performance of retired malaria-control workers with a reference group of retired guards and drivers, DDT-exposed workers did worse on tests assessing various neurobehavioural functions than controls; performance significantly deteriorated with increasing years of DDT application. Our results could not be explained by exposure to cholinesterase-inhibiting pesticides or other potential confounding factors.

引用

页码：1014 / 1016

页数：3