Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers

被引：278

作者：

Mimeault, M. ^{[1
]}

Hauke, R. ^{[1
]}

Mehta, P. P. ^{[1
]}

Batra, S. K. ^{[1
]}

机构：

[1] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2007年 / 11卷 / 05期

关键词：

cancer progenitor cells; oncogenic signalling; endothelial progenitor cells; chemotherapeutic treatments; drug resistance mechanisms; targeting therapies;

D O I：

10.1111/j.1582-4934.2007.00088.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Overcoming intrinsic and acquired resistance of cancer stem/ progenitor cells to current clinical treatments represents a major challenge in treating and curing the most aggressive and metastatic cancers. This review summarizes recent advances in our understanding of the cellular origin and molecular mechanisms at the basis of cancer initiation and progression as well as the heterogeneity of cancers arising from the malignant.

引用

页码：981 / 1011

页数：31

共 242 条

[1]

Prospective identification of tumorigenic breast cancer cells [J].