Cortical lesions and brain atrophy in MS

被引：99

作者：

Kutzelnigg, A ^{[1
]}

Lassmann, H ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Neuroimmunol, Ctr Brain Res, A-1090 Vienna, Austria

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2005年 / 233卷 / 1-2期

关键词：

multiple sclerosis; demyelination; cortical lesions; brain atrophy; disease progression;

D O I：

10.1016/j.jns.2005.03.027

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis is generally considered a disease of the white matter. However, this is only one pathological aspect of the disease as demyelination is prominent in the grey matter of deep cerebral nuclei and the cerebral cortex. In this review, we discuss the possibility that disease involvement of grey matter structures may significantly contribute to clinical disability in multiple sclerosis patients. (c) 200 Elsevier B.V. All rights reserved.

引用

页码：55 / 59

页数：5

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