Expression of glial cell line-derived neurotrophic factor and GDNFR-α mRNAs in human peripheral neuropathies

被引：19

作者：

Yamamoto, M

Mitsuma, N

Ito, Y

Hattori, N

Nagamatsu, M

Li, M

Mitsuma, T

Sobue, G

机构：

[1] Nagoya Univ, Sch Med, Dept Neurol, Showa Ku, Nagoya, Aichi 466, Japan

[2] Aichi Med Univ, Dept Internal Med 4, Div Neurol, Aichi, Japan

来源：

BRAIN RESEARCH | 1998年 / 809卷 / 02期

关键词：

GDNF; GDNFR-alpha; peripheral neuropathies; axonopathy; cell infiltration;

D O I：

10.1016/S0006-8993(98)00858-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The steady-state mRNA levels of glial cell line-derived neurotrophic factor (GDNF), GDNFR-alpha and RET were examined in various human peripheral neuropathies to determine the relationship with myelinated fiber pathology, and T cell and macrophage invasions in the diseased nerves. GDNF and GDNFR-alpha mRNA levels were elevated to variable extent in the diseased nerves, although they were not specific to the type of diseases. The increase of GDNER-alpha mRNA levels was correlated with the extent of the nerves with axonal pathology, and was proportional to the extent of invasion of the nerves by T cells and macrophages. The GDNF mRNA levels were not related to axonal, demyelinating pathology, or inflammatory cell invasions. RET mRNA expression was not detected in normal nor diseased nerves. The GDNF and GDNFR-alpha expression in the diseased human nerves is regulated by an underlying pathology-related process, and could play a role in peripheral nerve repair. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：175 / 181

页数：7

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