The changing epidemiology of type 1 diabetes: why is it going through the roof?

被引：152

作者：

Vehik, Kendra ^{[1
]}

Dabelea, Dana ^{[2
]}

机构：

[1] Univ S Florida, Pediat Epidemiol Ctr, Coll Med, Dept Pediat, Tampa, FL 33612 USA

[2] Univ Colorado Denver, Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2011年 / 27卷 / 01期

关键词：

type; 1; diabetes; epidemiology; incidence; AMERICAN YOUTH PREVALENCE; INCREASED LINEAR GROWTH; BETA-CELL AUTOIMMUNITY; ACCELERATOR HYPOTHESIS; INCREASING INCIDENCE; RISING INCIDENCE; CLINICAL CHARACTERISTICS; WEIGHT-GAIN; BODY-MASS; INTESTINAL PERMEABILITY;

D O I：

10.1002/dmrr.1141

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The incidence of type 1 diabetes is increasing and this may double the burden of disease in our youngest by 2020. The recent increase in incidence is mostly happening in the very young and those with moderate genetic susceptibility. Many environmental factors have been implicated, but no major determinants have been clearly identified, and the mechanisms of involvement remain elusive. This review summarizes current research efforts directed at understanding the possible reasons for this increase, including the role of viruses, gut microbiota, early life feeding patterns, perinatal factors and childhood growth patterns. It also provides a road map for future research directions. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：3 / 13

页数：11

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