Dexmedetomidine for neurological surgery

被引：149

作者：

Bekker, A

Sturaitis, MK

机构：

[1] Rush Univ, Med Ctr, Rush Med Coll, Dept Anesthesiol, Chicago, IL 60612 USA

[2] Rush Univ, Med Ctr, Rush Med Coll, Dept Neurosurg, Chicago, IL 60612 USA

[3] NYU, Med Ctr, Dept Anesthesiol, New York, NY 10016 USA

[4] NYU, Med Ctr, Dept Neurosurg, New York, NY 10016 USA

来源：

NEUROSURGERY | 2005年 / 57卷 / 01期

关键词：

alpha(2)-adrenoreceptor agonist; cerebral blood flow; dexmedetomidine; neuroanesthesia; neuromonitoring; neurophysiology; sedation;

D O I：

10.1227/01.NEU.0000163476.42034.A1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

DEXMEDETOMIDINE IS A new intravenous drug gaining popularity in neuroanesthesia and neurocritical care practice. This alpha(2)-adrenergic receptor agonist offers a unique cooperative sedation," anxiolysis, and analgesia with no respiratory depression. Cerebral effects are generally consistent with a desirable neurophysiological profile, including neuroprotective characteristics. In addition, sympatholytic and antinociceptive properties allow for hemodynamic stability at critical moments of neurosurgical stimulation. This review will address the neuropharmacology and neurophysiology of alpha(2)-adrenergic agonists and will specifically consider the rapidly evolving applicability of dexmedetomidine as an adjuvant to neurosurgical case management.

引用

页码：1 / 9

页数：9

共 97 条

[1] The efficacy of demedetomidine versus morphine for postoperative analgesia after major inpatient surgery [J].