RNA: Guiding gene silencing

被引：301

作者：

Matzke, M

Matzke, AJM

Kooter, JM

机构：

[1] Austrian Acad Sci, Inst Mol Biol, A-5020 Salzburg, Austria

[2] Vrije Univ Amsterdam, Dept Dev Genet, Amsterdam, Netherlands

来源：

SCIENCE | 2001年 / 293卷 / 5532期

关键词：

D O I：

10.1126/science.1063051

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences. RNA silencing is a potent means to counteract foreign sequences and could play an important role in plant and animal development.

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收藏

页码：1080 / 1083

页数：4

相关论文

共 53 条

[1]

Chromodomains are protein-RNA interaction modules [J].

Akhtar, A ;

Zink, D ;

Becker, PB .

NATURE, 2000, 407 (6802) :405-409

[2]

Genome-wide RNAi [J].

Barstead, R .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2001, 5 (01) :63-66

[3]

Role for a bidentate ribonuclease in the initiation step of RNA interference [J].

Bernstein, E ;

Caudy, AA ;

Hammond, SM ;

Hannon, GJ .

NATURE, 2001, 409 (6818) :363-366

[4]

The DNA methyltransferases of mammals [J].

Bestor, TH .

HUMAN MOLECULAR GENETICS, 2000, 9 (16) :2395-2402

[5]

Conserved plant genes with similarity to mammalian de novo DNA methyltransferases [J].

Cao, XF ;

Springer, NM ;

Muszynski, MG ;

Phillips, RL ;

Kaeppler, S ;

Jacobsen, SE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4979-4984

[6]

Gene silencing by double-stranded RNA [J].

Carthew, RW .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (02) :244-248

[7]

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain [J].

Cerutti, L ;

Mian, N ;

Bateman, A .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (10) :481-482

[8]

Post-transcriptional gene silencing across kingdoms [J].

Cogoni, C ;

Macino, G .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (06) :638-643

[9]

DAVIDSON EH, 1979, SCIENCE, V204, P1051

[10]

Structural genomics of RNA [J].

Doudna, JA .

NATURE STRUCTURAL BIOLOGY, 2000, 7 (Suppl 11) :954-956

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