A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

被引：407

作者：

Pendyala, Swaroop ^{[1
]}

Walker, Jeanne M. ^{[1
]}

Holt, Peter R. ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Biochem Genet & Metab, New York, NY 10065 USA

来源：

GASTROENTEROLOGY | 2012年 / 142卷 / 05期

关键词：

Gastrointestinal Barrier Function; Immune Response; Circulating Cytokines; LPS; INDUCED OBESITY; INFLAMMATION; MICE; MICROBIOTA; MECHANISM; PERMEABILITY;

D O I：

10.1053/j.gastro.2012.01.034

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Endotoxemia, characterized by an excess of circulating bacterial wall lipopolysaccharide, is associated with systemic inflammation and the metabolic syndrome. Placing 8 healthy subjects on a Western-style diet for 1 month induced a 71% increase in plasma levels of endotoxin activity (endotoxemia), whereas a prudent-style diet reduced levels by 31%. The Western-style diet might, therefore, contribute to endotoxemia by causing changes in gastrointestinal barrier function or the composition of the microbiota. Endotoxemia might also develop in individuals with gastrointestinal barrier impairment. Therapeutic reagents that reduce endotoxemia might reduce systemic inflammation in patients with gastrointestinal diseases or metabolic syndrome.

引用

页码：1100 / +

页数：4

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