Presence and potent immunosuppressive role of interleukin-10 in malignant pleural effusion due to lung cancer

被引：12

作者：

Yanagawa, H

Takeuchi, E

Suzuki, Y

Ohmoto, Y

Bando, H

Sone, S

机构：

[1] Univ Tokushima, Sch Med, Dept Internal Med 3, Tokushima 7708503, Japan

[2] Tokushima Prefectural Cent Hosp, Dept Resp Dis, Tokushima 7700042, Japan

来源：

CANCER LETTERS | 1999年 / 136卷 / 01期

关键词：

interleukin-10; pleural effusion; lung cancer; pleural macrophages; local immune response;

D O I：

10.1016/S0304-3835(98)00299-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The presence and possible role of interleukin (LL)-10 were examined in malignant pleural effusion due to lung cancer. In 37 out of 55 cases examined, IL-10 was detectable in pleural effusion and the mean level with standard error was 62.1 +/- 12.1 pg/ml Spontaneous and lipopolysaccharide-induced production of anti-tumor cytokines such as IL-1 beta and tumor necrosis factor (TNF)-alpha, by pleural macrophages, obtained from five patients with malignant pleurisy, were suppressed by IL-10. These findings suggest that IL-10 is present in the tumor-growing site and acts as a suppressive factor of local anti-tumor immunity in humans. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

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页码：27 / 32

页数：6

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