The humoral response to the tumor-suppressor gene-product p53 in human cancer: Implications for diagnosis and therapy

被引：83

作者：

Soussi, T

机构：

[1] Institut de Genetique Moleculaire, University P. et M. Curie, INSERM

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 08期

关键词：

D O I：

10.1016/0167-5699(96)30019-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutation of the tumor-suppressor gene y53 appears to be an important trigger for the development of a humoral response in cancer patients. As discussed here, diagnosis of an alteration in p53 can be used as a marker of unfavorable prognosis and indicate a potential target for immunotherapy.

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页码：354 / 356

页数：3

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