Preemptive renal transplantation: Why not?

被引：49

作者：

Mange, KC ^{[1
]}

Weir, MR

机构：

[1] Univ Penn, Sch Med, Div Renal Electrolyte & Hypertens, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

[3] Univ Maryland, Ctr Med, Div Nephrol, Baltimore, MD 21201 USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2003年 / 3卷 / 11期

关键词：

dialysis; reemptive; renal transplantation;

D O I：

10.1046/j.1600-6143.2003.00232.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Dialysis has been the long-established initial choice of treatment for persons with end-stage renal disease. Transplantation before dialysis, or preemptive renal transplantation (PRT), has been controversial because of the paucity of clinical evidence that has clarified the benefits vs. risks of this approach. However, several recent observational analyses indicate that PRT is the optimal strategy to benefit patients requiring renal replacement therapy. This current review will discuss the advantages that are associated with PRT, and will summarize studies that have investigated the impact of the timing of transplantation on outcomes. We will also discuss the utility of PRT from various perspectives, and describe the challenges ahead in expanding the opportunity of PRT for more patients.

引用

页码：1336 / 1340

页数：5

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