Advanced testicular cancer: Update for urologists

被引：26

作者：

Einhorn, LH ^{[1
]}

Donohue, JP ^{[1
]}

机构：

[1] Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA

来源：

JOURNAL OF UROLOGY | 1998年 / 160卷 / 06期

关键词：

testicular neoplasms; drug therapy; cisplatin;

D O I：

10.1016/S0022-5347(01)62213-4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: Testicular cancer is a model for a curable neoplasm. We review past and present accomplishments in treating testis cancer and emphasize controversial surgical issues of interest to the urologist. Materials and Methods: We reviewed early and recent chemotherapy trials of germ cell tumors, stressing random prospective phase III studies. In addition, we address specific and complicated issues that are of particular relevance for the urologist, analyzing recently published articles. Results: Cisplatin combination chemotherapy has dramatically improved the cure rate for patients with germ cell tumors. The indications for post-chemotherapy resection for residual masses are discussed. Conclusions: The major goal 25 years ago was to develop a successful chemotherapy regimen for disseminated disease, which has now been accomplished with cisplatin combination chemotherapy. Present issues include optimal treatment in patients with poor prognostic characteristics, salvage chemotherapy strategies and indications for past-chemotherapy surgical resection.

引用

页码：1964 / 1969

页数：6

共 54 条

[1]

[Anonymous], 1997, J Clin Oncol, V15, P594

[2] RANDOMIZED TRIAL OF ETOPOSIDE AND CISPLATIN VERSUS ETOPOSIDE AND CARBOPLATIN IN PATIENTS WITH GOOD-RISK GERM-CELL TUMORS - A MULTIINSTITUTIONAL STUDY [J].

BAJORIN, DF ;

SAROSDY, MF ;

PFISTER, DG ;

MAZUMDAR, M ;

MOTZER, RJ ;

SCHER, HI ;

GELLER, NL ;

FAIR, WR ;

HERR, H ;

SOGANI, P ;

SHEINFELD, J ;

RUSSO, P ;

VLAMIS, V ;

CAREY, R ;

VOGELZANG, NJ ;

CRAWFORD, ED ;

BOSL, GJ .

JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (04) :598-606

[3]

BAJORIN DF, 1991, CANCER, V67, P28, DOI 10.1002/1097-0142(19910101)67:1<28::AID-CNCR2820670106>3.0.CO

[4]

2-3

[5] LATE RELAPSE OF TESTICULAR CANCER [J].

BANIEL, J ;

FOSTER, RS ;

GONIN, R ;

MESSEMER, JE ;

DONOHUE, JP ;

EINHORN, LH .

JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (05) :1170-1176

[6] PROGNOSTIC FACTORS FOR FAVORABLE OUTCOME IN DISSEMINATED GERM-CELL TUMORS [J].

BIRCH, R ;

WILLIAMS, S ;

CONE, A ;

EINHORN, L ;

ROARK, P ;

TURNER, S ;

GRECO, FA .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (03) :400-407

[7] VAB-6 - AN EFFECTIVE CHEMOTHERAPY REGIMEN FOR PATIENTS WITH GERM-CELL TUMORS [J].

BOSL, GJ ;

GLUCKMAN, R ;

GELLER, NL ;

GOLBEY, RB ;

WHITMORE, WF ;

HERR, H ;

SOGANI, P ;

MORSE, M ;

MARTINI, N ;

BAINS, M ;

MCCORMACK, P .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (10) :1493-1499

[8] Testicular germ-cell cancer [J].

Bosl, GJ ;

Motzer, RJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (04) :242-253

[9] A RANDOMIZED TRIAL OF ETOPOSIDE + CISPLATIN VERSUS VINBLASTINE + BLEOMYCIN + CISPLATIN + CYCLOPHOSPHAMIDE + DACTINOMYCIN IN PATIENTS WITH GOOD-PROGNOSIS GERM-CELL TUMORS [J].

BOSL, GJ ;

GELLER, NL ;

BAJORIN, D ;

LEITNER, SP ;

YAGODA, A ;

GOLBEY, RB ;

SCHER, H ;

VOGELZANG, NJ ;

AUMAN, J ;

CAREY, R ;

FAIR, WR ;

HERR, H ;

MORSE, M ;

SOGANI, P ;

WHITMORE, W .

JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (08) :1231-1238

[10] Simultaneous retroperitoneal, thoracic, and cervical resection of postchemotherapy residual masses in patients with metastatic nonseminomatous germ cell tumors of the testis [J].

Brenner, PC ;

Herr, HW ;

Morse, MJ ;

Sheinfeld, J ;

Aprikian, A ;

Bosl, GJ ;

Motzer, RJ ;

Bajorin, DF ;

Schantz, S ;

Fair, WR ;

Burt, M .

JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (06) :1765-1769

← 1 2 3 4 5 6 →