LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells

被引：42

作者：

Sarker, MR

Sory, MP

Boyd, AP

Iriarte, M

Cornelis, GR

机构：

[1] Univ Catholique Louvain, Microbial Pathogenesis Unit, UCL 7449, Christian de Duve Inst Cellular Pathol, B-1200 Brussels, Belgium

[2] Univ Catholique Louvain, Fac Med, B-1200 Brussels, Belgium

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 06期

关键词：

D O I：

10.1128/IAI.66.6.2976-2979.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

引用

页码：2976 / 2979

页数：4

共 37 条

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