Molecular cloning and tissue distribution of rat peptide transporter PEPT2

被引：146

作者：

Saito, H

Terada, T

Okuda, M

Sasaki, S

Inui, K

机构：

[1] KYOTO UNIV HOSP,FAC MED,DEPT PHARM,SAKYO KU,KYOTO 60601,JAPAN

[2] TOKYO MED & DENT UNIV,SCH MED,DEPT INTERNAL MED 2,TOKYO 113,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1996年 / 1280卷 / 02期

关键词：

peptide transport; proton-coupled transporter; cDNA; sequence; bestatin; renal tubular reabsorption;

D O I：

10.1016/0005-2736(96)00024-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA encoding rat H+-coupled peptide transporter PEPT2 was isolated. The cDNA encoded a protein of 729 amino acids with 48% amino acid identity to the rat PEPT1. The mRNA expression of rat PEPT2 was predominant in the kidney. When expressed in Xenopus oocytes, rat PEPT2 stimulated the uptake of bestatin, a dipeptide-like drug.

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页码：173 / 177

页数：5

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