Genetic determinants of cutaneous malignant melanoma in Sinclair swine

被引：25

作者：

Blangero, J

Tissot, RG

Beattie, CW

Amoss, MS

机构：

[1] UNIV ILLINOIS, DEPT GENET, CHICAGO, IL 60612 USA

[2] USDA ARS, US MEAT ANIM RES CTR, CLAY CTR, NE 68933 USA

[3] TEXAS A&M UNIV, COLL VET MED, DEPT VET PHYSIOL & PHARMACOL, COLLEGE STN, TX 77843 USA

来源：

BRITISH JOURNAL OF CANCER | 1996年 / 73卷 / 05期

关键词：

melanoma; segregation analysis; linkage analysis; animal model;

D O I：

10.1038/bjc.1996.116

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of genetic Factors involved in the determination of risk of cutaneous malignant melanoma (CMM) in humans remains unclear owing to genetic heterogeneity and reliance on simplistic models of inheritance. Here, we report a statistical genetic analysis of cutaneous malignant melanoma in Sinclair swine (SSCM), a unique animal model for human CMM. Using complex segregation analysis a two-locus model involving an unknown major locus and a second locus that lies within or close to the swine leucocytic antigen (SLA) complex jointly determine risk of SSCM in pedigreed animals. These loci also influence severity of affection, accounting for approximately 20% of the phenotypic variation in quantitative tumour burden.

引用

页码：667 / 671

页数：5

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