A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei

被引：31

作者：

Liang, Yong-hong ^{[1
]}

Wang, Wei ^{[2
]}

Yu, Si-wang ^{[1
]}

Ye, Min ^{[1
]}

He, Xiang-hui ^{[1
]}

Gong, Ning-bo ^{[3
,4
]}

Lu, Yang ^{[3
,4
]}

Khan, Ikhlas A. ^{[2
]}

Guo, De-an ^{[1
,5
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

[2] Univ Mississippi, Sino US TCM Res Ctr, Natl Ctr Nat Prod Res, Inst Pharmaceut Sci, University, MS 38677 USA

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

[5] CAS, Shanghai Res Ctr Modernizat TCM, Shanghai Inst Mat Med, Shanghai, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 08期

关键词：

Drynaria fortunei; Polypodiaceae; Triterpenoid; Chiratane; Cytotoxic activity; DRYOPTERIS-CRASSIRHIZOMA; SWERTIA-CHIRATA; NMR-SPECTRA; HOPANE; CONSTITUENTS; LEAVES;

D O I：

10.1016/j.fitote.2010.06.013

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20 beta-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC50 of 2.92 mu M, 1.08 mu M and 2.45 mu M, respectively. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：988 / 991

页数：4

共 19 条

[1]

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[2]

AGETA H, 1993, CHEM PHARM BULL, V41, P1939

[3]

CHAKRAVARTY AK, 1990, TETRAHEDRON LETT, V31, P7649

[4]

Chakravarty AK, 2001, INDIAN J CHEM B, V40, P228