Factors Involved in Formulation of Oily Delivery System for Proteins Based on PEG-8 Caprylic/Capric Glycerides and Polyglyceryl-6 Dioleate in a Mixture of Oleic Acid with Chitosan

被引：11

作者：

Assaf, Shereen M. ^{[2
]}

Al-Jbour, Nawzat D. ^{[1
]}

Eftaiha, Ala'a F. ^{[3
]}

Elsayed, Amani M. ^{[4
]}

Al-Remawi, Mayyas M. ^{[4
]}

Qinna, Nidal A. ^{[5
]}

Chowdhry, Babur ^{[6
]}

Leharne, Stephen ^{[6
]}

Badwan, Adnan A. ^{[1
]}

机构：

[1] Suwagh Drug Delivery Syst, Naur, Jordan

[2] Jordan Univ Sci & Technol, Fac Pharm, Dept Pharmaceut Technol, Irbid, Jordan

[3] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 0W0, Canada

[4] Taif Univ, Coll Pharm, Dept Pharmaceut & Pharmaceut Technol, At Taif, Saudi Arabia

[5] Petra Univ, Dept Pharmacol, Fac Pharm, Amman, Jordan

[6] Univ Greenwich, Sch Sci, Chatham ME4 4TB, Kent, England

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2011年 / 32卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

Chitosan; insulin; microemulsion; oily system; protein delivery; DRUG-DELIVERY; MOLECULAR-WEIGHT; ORAL ABSORPTION; MICROEMULSION; NANOPARTICLES; RATS;

D O I：

10.1080/01932691003659775

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Systematic experimental work is required to improve knowledge related to the use of oily delivery systems. This work aimed to examine the influence of different molecular weights chitosan on formation and solubilization ability of w/o system of Labrasol, Plurol Oleique, water and oleic acid. Phase diagrams were constructed. Size measurements were performed for each surfactant in oleic acid. Interfacial tension of chitosan was measured between oleic acid and water at pH 1.5 and 6.25. Effect of chitosan on microemulsion size was studied. When used to deliver rh-insulin to diabetic rats, the mixture showed reduction in blood glucose compared to control.

引用

页码：623 / 633

页数：11

共 38 条

[1]

Uptake of PMMA nanoparticles from the gastrointestinal tract after oral administration to rats:: modification of the body distribution after suspension in surfactant solutions and in oil vehicles [J].

Araujo, L ;

Sheppard, M ;

Löbenberg, R ;

Kreuter, J .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 176 (02) :209-224

[2]

ATTWOOD D, 1983, AGGREGATION PROCESSE, P211

[3]

Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications [J].

Berger, J ;

Reist, M ;

Mayer, JM ;

Felt, O ;

Peppas, NA ;

Gurny, R .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 57 (01) :19-34

[4]

Influence of molecular weight on oral absorption of water soluble chitosans [J].

Chae, SY ;

Jang, MK ;

Nah, JW .

JOURNAL OF CONTROLLED RELEASE, 2005, 102 (02) :383-394

[5]

Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme [J].

Cheng, Mao-Bo ;

Wang, Jian-Cheng ;

Li, Yu-Hua ;

Liu, Xiao-Yan ;

Zhang, Xuan ;

Chen, Da-Wei ;

Zhou, Shu-Feng ;

Zhang, Qiang .

JOURNAL OF CONTROLLED RELEASE, 2008, 129 (01) :41-48

[6]

A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration:: Investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats [J].

Çilek, A ;

Çelebi, N ;

Tirnaksiz, F ;

Tay, A .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2005, 298 (01) :176-185

[7]

LIPID MICROEMULSIONS FOR IMPROVING DRUG DISSOLUTION AND ORAL ABSORPTION - PHYSICAL AND BIOPHARMACEUTICAL ASPECTS [J].

CONSTANTINIDES, PP .

PHARMACEUTICAL RESEARCH, 1995, 12 (11) :1561-1572

[8]

DELGADOCHARRO MB, 1995, B TECH GATTEFOSSE, V88, P55

[9]

Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach [J].

des Rieux, Anne ;

Fievez, Virginie ;

Garinot, Marie ;

Schneider, Yves-Jacques ;

Preat, Veronique .

JOURNAL OF CONTROLLED RELEASE, 2006, 116 (01) :1-27

[10]

The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems [J].

Djekic, Ljijana ;

Ibric, Svetlana ;

Primorac, Marija .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 361 (1-2) :41-46

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